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About The Journal

Journal of Fluoroorganic Chemistry (JFC) is a broad field of organic chemistry, and its related disciplines are medicinal chemistry, bio-organic chemistry, and pharmaceutical chemistry. JFC provides rapid dissemination of original research articles, reviews, short communications, rapid communications, and abstracts. Rapid communications and abstracts of such research preserve their research credibility and to transmit their new contributions quickly to other researchers and the public. Fluoroorganic chemistry describes the chemistry of the organofluorines, organic compounds that contain the carbon–fluorine bond. Organofluorine compounds find diverse applications ranging from oil and water repellents to pharmaceuticals, refrigerants, and reagents in catalysis. In addition to these applications, some organofluorine compounds are pollutants because of their contributions to ozone depletion, global warming, bioaccumulation, and toxicity. The area of organofluorine chemistry often requires special techniques associated with the handling of fluorinating agents. Biologically synthesized Fluoroorganic have been found in microorganisms and plants, but not animals. The most common example is fluoroacetate, which occurs as a plant defence against herbivores in at least 40 plants in Australia, Brazil and Africa. Other biologically synthesized organofluorines include ω-fluoro fatty acids, fluoroacetone, and 2-fluorocitrate which are all believed to be biosynthesized in biochemical pathways from the intermediate fluoroacetaldehyde. Adenosyl-fluoride synthase is an enzyme capable of biologically synthesizing the carbon–fluorine bond. Man made carbon–fluorine bonds are commonly found in pharmaceuticals and agrochemicals because it adds stability to the carbon framework; also, the relatively small size of fluorine is convenient as fluorine acts as an approximate bioisostere of the hydroxyl group. Introducing the carbon–fluorine bond to organic compounds is the major challenge for medicinal chemists using Fluoroorganic chemistry, as the carbon–fluorine bond increases the probability of having a successful drug by about a factor of ten. An estimated 20% of pharmaceuticals, and 30–40% of agrichemicals are organofluorines, including several of the top drugs. Organofluorine chemistry impacts many areas of everyday life and technology. The C-F bond is found in pharmaceuticals, agrichemicals, fluoropolymers, refrigerants, surfactants, anesthetics, oil-repellents, catalysis, and water-repellents, among others.The carbon-fluorine bond is commonly found in pharmaceuticals and agrochemicals because it is generally metabolically stable and fluorine acts as a bioisostere of the hydrogen atom. An estimated one fifth of pharmaceuticals contain fluorine, including several of the top drugs. Examples include 5-fluorouracil, flunitrazepam (Rohypnol), fluoxetine (Prozac), paroxetine (Paxil), ciprofloxacin (Cipro), mefloquine, and fluconazole. Fluorine-substituted ethers are volatile anesthetics, including the commercial products methoxyflurane, enflurane, isoflurane, sevoflurane and desflurane. Fluorocarbon anesthetics reduce the hazard of flammability with diethyl ether and cyclopropane. Perfluorinated alkanes are used as blood substitutes.

Aim and Scope

Sciforce Journal of Fluoroorganic Chemistry  (JFC) journals and research papers are a gateway to the community of Fluoroorganic Chemistry experts, researchers and peers. While adhering to the international standards of online publishing, JFC aims to publish high quality, informative, scientific and well-researched content.

Journal of Fluoroorganic Chemistry